Article
The molecular genetics of type 1 diabetes: new genes and emerging mechanisms.
Trends in molecular medicine - 1 Jun 2008
Ounissi-Benkalha Houria, Polychronakos Constantin
Abstract excerpt
Susceptibility to type 1 diabetes (T1D) is determined by complex interactions between several genetic loci and environmental factors. Alleles at the human leukocyte antigen (HLA) locus explain up to 50% of the familial clustering of T1D, and the remainder is contributed to by multiple loci, of which only four were known until recently. First-stage results of genome-wide association (GWA) studies performed with...
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