Article
A genome-wide search for linkage-disequilibrium with type 1 diabetes in a recent genetically isolated population from the Netherlands.
Diabetes - 1 Mar 2002
Vaessen Norbert, Heutink Peter, Houwing-Duistermaat Jeanine J, Snijders Pieter J L M, Rademaker Tessa, Testers Leon, Batstra Manou R, Sandkuijl Lodewijk A, van Duijn Cornelia M, Oostra Ben A
Abstract excerpt
Type 1 diabetes has a substantial genetic component, with consistent evidence for a susceptibility locus in the HLA-DR/DQ region (chromosome 6p) and the insulin gene region (chromosome 11p). Genome scans have identified >18 other genomic regions that may harbor putative type 1 diabetes genes. However, evidence for most regions varies in different data sets. Given the genetic heterogeneity of type 1 diabetes,...
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