Article
Atorvastatin causes depressor and sympatho-inhibitory effects with upregulation of nitric oxide synthases in stroke-prone spontaneously hypertensive rats.
Journal of hypertension - 1 Feb 2003
Kishi Takuya, Hirooka Yoshitaka, Mukai Yasushi, Shimokawa Hiroaki, Takeshita Akira
Abstract excerpt
OBJECTIVE: Recent studies have suggested that statins decrease blood pressure in hypertensive animals and upregulate endothelial nitric oxide synthase (eNOS) expression. However, the effects of statins on the expression of nitric oxide synthase (NOS) in the brain and the sympathetic nervous system remain to be elucidated. The aim of this study was thus to examine the effects of atorvastatin on blood pressure,...
Topics
- Animals
- Antihypertensive Agents
- Aorta
- Atorvastatin
- Blood Pressure
- Brain
- Genetic Predisposition to Disease
- Heart Rate
- Heptanoic Acids
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Hypertension
- Isoenzymes
- Lipids