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The Human Interferon- and Estrogen-Regulated <i>ISG20/HEM45</i> Gene Product Degrades Single-Stranded RNA and DNA in Vitro

19 May 2001

Abstract excerpt

The human ISG20/HEM45 gene was identified independently on the basis of its increased level of expression in response to either interferon or estrogen hormone. Notably, the encoded protein is homologous with members of the 3' to 5' exonuclease superfamily that includes RNases T and D, and the proofreading domain of Escherichia coli DNA polymerase I. We provide here direct biochemical evidence that Isg20 acts as a...

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PMID: 11401564
DOI: 10.1021/bi010141t

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