Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility.

Journal of neurochemistry - 1 Dec 2002

Sahara Naruhiko, Lewis Jada, DeTure Michael, McGowan Eileen, Dickson Dennis W, Hutton Mike, Yen Shu-Hui

Abstract excerpt

Transgenic mice (JNPL3), which develop neurofibrillary degeneration and express four-repeat human tau with P301L missense mutation, were characterized biochemically to determine whether the development of aggregated tau from soluble tau involves an intermediate stage. Homogenates from mice of different ages were separated into buffer-soluble (S1), sarkosyl- and salt-extractable (S2) and sarkosyl-insoluble pellet...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Chemistry
Share to Detergents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Polyacrylamide Gel

Share to Macromolecular Substances

Share to Sex Factors

Share to Solubility

Share to tau Proteins

Share to Tauopathies

Source

Identifiers

PMID: 12472903
DOI: 10.1046/j.1471-4159.2002.01241.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility.PMID 12472903Read ↗

Tau filament formation in transgenic mice expressing P301L tau.Semantic proximity Read ↗

Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia.Semantic proximity Read ↗

Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)Semantic proximity Read ↗

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse modelSemantic proximity Read ↗

Common mouse models of tauopathy reflect early but not late human diseaseSemantic proximity Read ↗

The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition.Semantic proximity Read ↗

Are Tau Aggregates Toxic or Protective in Tauopathies?Semantic proximity Read ↗

Cryo-EM structure of pro-aggregant P301L/S320F double-mutant tau filaments formed in mouse brains following peripheral AAV deliverySemantic proximity Read ↗

Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice.Semantic proximity Read ↗

Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice.Semantic proximity Read ↗

Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutation.Semantic proximity Read ↗

Seed-competent tau monomer initiates pathology in PS19 tauopathy miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.