Article
Targeted replacement of mouse apolipoprotein A-I with human ApoA-I or the mutant ApoA-IMilano. Evidence of APOA-IM impaired hepatic secretion.
The Journal of biological chemistry - 14 Feb 2003
Parolini Cinzia, Chiesa Giulia, Zhu Yiwen, Forte Trudy, Caligari Silvia, Gianazza Elisabetta, Sacco Maria Grazia, Sirtori Cesare R, Rubin Edward M
Abstract excerpt
Despite a pro-atherogenic profile, individuals carrying the molecular variant (R173C) of apolipoprotein (apo)A-I, named apoA-I(Milano) (apoA-I(M)), appear to be at reduced risk for cardiovascular disease. To develop an in vivo system to explore, in a controlled manner, the effects of apoA-I(M) on lipid metabolism, we have used the gene targeting technology, or "gene knock-in" (gene k-in), to replace the murine...
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