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Article

Apolipoprotein CI causes hypertriglyceridemia independent of the very-low-density lipoprotein receptor and apolipoprotein CIII in mice.

Biochimica et biophysica acta - 1 Feb 2006

van der Hoogt Caroline C, Berbée Jimmy F P, Espirito Santo Sonia M S, Gerritsen Gery, Krom Yvonne D, van der Zee André, Havekes Louis M, van Dijk Ko Willems, Rensen Patrick C N

Abstract excerpt

We have recently shown that the predominant hypertriglyceridemia in human apolipoprotein C1 (APOC1) transgenic mice is mainly explained by apoCI-mediated inhibition of the lipoprotein lipase (LPL)-dependent triglyceride (TG)-hydrolysis pathway. Since the very-low-density lipoprotein receptor (VLDLr) and apoCIII are potent modifiers of LPL activity, our current aim was to study whether the lipolysis-inhibiting...

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Source

Identifiers

PMID: 16478678
DOI: 10.1016/j.bbalip.2006.01.002

Genes

LPL
APOC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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