Article
Apolipoprotein A-I and the molecular variant apoA-I(Milano): evaluation of the antiatherogenic effects in knock-in mouse model.
Atherosclerosis - 1 Dec 2005
Parolini Cinzia, Chiesa Giulia, Gong Elaine, Caligari Silvia, Cortese Miriam M, Koga Teiichiro, Forte Trudy M, Rubin Edward M
Abstract excerpt
No evidence of premature vascular disease is found in apolipoprotein A-I(Milano) (apoA-I(M)) human carriers, despite very low high density lipoprotein (HDL) cholesterol levels. Whether apoA-I(M) may impart a "gain of function" in atherosclerosis protection compared to wild-type apoA-I is hotly debated. To address this question, knock-in mice expressing human apoA-I or apoA-I(M) were crossed with...
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