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Article

Hypertriglyceridemia as a Result of Human apo <i>CII</i> Gene Expression in Transgenic Mice

17 Aug 1990

Abstract excerpt

Primary and secondary hypertriglyceridemia is common in the general population, but the biochemical basis for this disease is largely unknown. With the use of transgenic technology, two lines of mice were created that express the human apolipoprotein CIII gene. One of these mouse lines with 100 copies of the gene was found to express large amounts of the protein and to be severely hypertriglyceridemic. The other...

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PMID: 2167514
DOI: 10.1126/science.2167514

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