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Article

Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22.

The Journal of biological chemistry - 28 Feb 2003

Gupta Rajnish A, Sarraf Pasha, Brockman Jeffrey A, Shappell Scott B, Raftery Laurel A, Willson Timothy M, DuBois Raymond N

Abstract excerpt

Peroxisome proliferator-activated receptor gamma (PPARgamma) and transforming growth factor-beta (TGF-beta) are key regulators of epithelial cell biology. However, the molecular mechanisms by which either pathway induces growth inhibition and differentiation are incompletely understood. We have identified transforming growth factor-simulated clone-22 (TSC-22) as a target gene of both pathways in intestinal...

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PMID: 12468551
DOI: 10.1074/jbc.M208076200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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