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Article

Bunched, the Drosophila homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth.

BMC developmental biology - 28 Jan 2008

Gluderer Silvia, Oldham Sean, Rintelen Felix, Sulzer Andrea, Schütt Corina, Wu Xiaodong, Raftery Laurel A, Hafen Ernst, Stocker Hugo

Abstract excerpt

BACKGROUND: Transforming Growth Factor-beta1 stimulated clone-22 (TSC-22) is assumed to act as a negative growth regulator and tumor suppressor. TSC-22 belongs to a family of putative transcription factors encoded by four distinct loci in mammals. Possible redundancy among the members of the TSC-22/Dip/Bun protein family complicates a genetic analysis. In Drosophila, all proteins homologous to the TSC-22/Dip/Bun...

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PMID: 18226226
DOI: 10.1186/1471-213X-8-10
PMCID: PMC2253523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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