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Article

Peroxisome proliferator-activated receptor gamma-mediated differentiation: a mutation in colon cancer cells reveals divergent and cell type-specific mechanisms.

The Journal of biological chemistry - 20 Jun 2003

Gupta Rajnish A, Sarraf Pasha, Mueller Elisabetta, Brockman Jeffrey A, Prusakiewicz Jeffery J, Eng Charis, Willson Timothy M, DuBois Raymond N

Abstract excerpt

Activation of the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma) inhibits cell growth and induces differentiation in both adipocyte and epithelial cell lineages, although it is unclear whether this occurs through common or cell-type specific mechanisms. We have identified four human colon cancer cell lines that do no undergo growth inhibition or induce markers of...

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Share to Amino Acid Substitution
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to Mutagenesis, Site-Directed

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Share to Protein Conformation

Share to Receptors, Cytoplasmic and Nuclear

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 12591919
DOI: 10.1074/jbc.M300637200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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