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Article

HSF1 is a transcriptional activator of IL-10 gene expression in RAW264.7 macrophages.

Inflammation - 1 Aug 2012

Zhang Huali, Zhang Lingli, Yu Fengxiu, Liu Ying, Liang Qiujuan, Deng Gonghua, Chen Guangwen, Liu Meidong, Xiao Xianzhong

Abstract excerpt

The heat shock transcription factor (HSF) is an important transactivator of the heat shock genes. Recent studies have shown that HSF1 acts as a repressor of non-heat shock genes to protect against endotoxemia. In this study, we found that heat shock treatment and HSF1 over-expression augmented the induction of interleukin (IL)-10 mRNA. Computational analysis of the mouse IL-10 promoter region showed that three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22549481
DOI: 10.1007/s10753-012-9471-4

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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HSF1 is a transcriptional activator of IL-10 gene expression in RAW264.7 macrophages.PMID 22549481Read ↗

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