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Article

Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity.

PloS one - 1 Jan 2013

He Minghao, Zhang Linlin, Wang Xincheng, Huo Lihong, Sun Lei, Feng Chengye, Jing Xutian, Du Danyao, Liang Huabin, Liu Min, Hong Zhangyong, Zhou Jun

Abstract excerpt

The Tat protein of HIV-1 has several well-known properties, such as nucleocytoplasmic trafficking, transactivation of transcription, interaction with tubulin, regulation of mitotic progression, and induction of apoptosis. Previous studies have identified a couple of lysine residues in Tat that are essential for its functions. In order to analyze the functions of all the lysine residues in Tat, we mutated them...

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Identifiers

PMID: 23826228
DOI: 10.1371/journal.pone.0067186
PMCID: PMC3695041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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