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Article

CYP2B6 gene single nucleotide polymorphisms and leukemia susceptibility.

Annals of hematology - 1 Mar 2011

Yuan Zhong-hai, Liu Qian, Zhang Ying, Liu Hong-xing, Zhao Jun, Zhu Ping

Abstract excerpt

CYP2B6 is a highly variable and polymorphic cytochrome P450 enzyme which plays a vital role in the degradation of some endogenous metabolites, xenobiotics, and harmful compounds. The 516G>T single nucleotide polymorphism (SNP) in exon 4 of CYP2B6 gene may change CYP2B6 enzyme activity and the gene expression in the liver. Carcinogens' failure to be degraded by CYP2B6 may cause DNA injury and cancer. Here, we...

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PMID: 20878158
DOI: 10.1007/s00277-010-1085-z

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