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Article

Outersphere and innersphere coordinated metal ions in an aminoacyl-tRNA synthetase ribozyme.

Nucleic acids research - 1 Dec 2002

Saito Hirohide, Suga Hiroaki

Abstract excerpt

Metal ions are essential cofactors for various ribozymes. Here we dissect the roles of metal ions in an aminoacyl-tRNA synthetase-like ribozyme (ARS ribozyme), which was evolved in vitro. This ribozyme can charge phenylalanine on tRNA in cis, where it is covalently attached to the 5'-end of tRNA (i.e. a form of precursor tRNA), as well as in trans, where it can act as a catalyst. The presence of magnesium ion is...

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Identifiers

PMID: 12466539
DOI: 10.1093/nar/gkf641
PMCID: PMC137956

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Source receipt: pubmed, retrieved 7 Sept 2026.

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