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Article

Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease.

Nature medicine - 1 Jan 2003

Ghoreschi Kamran, Thomas Peter, Breit Susanne, Dugas Martin, Mailhammer Reinhard, van Eden Willem, van der Zee Ruurd, Biedermann Tilo, Prinz Jörg, Mack Matthias, Mrowietz Ulrich, Christophers Enno, Schlöndorff Detlef, Plewig Gerd, Sander Christian A, Röcken Martin

Abstract excerpt

Selective skewing of autoreactive interferon-gamma (IFN-gamma)-producing T helper cells (Th1) toward an interleukin-4 (IL-4)-producing (Th2) phenotype can in experimental animals alleviate autoimmune disease without inducing general immunosuppression. In a prospective dose escalation study, we assessed treatment with human IL-4 (rhuIL-4) in 20 patients with severe psoriasis. The therapy was well tolerated, and...

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PMID: 12461524
DOI: 10.1038/nm804

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CCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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