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Article

Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling

16 Nov 2009

Abstract excerpt

Th subsets are defined according to their production of lineage-indicating cytokines and functions. In this study, we have identified a subset of human Th cells that infiltrates the epidermis in individuals with inflammatory skin disorders and is characterized by the secretion of IL-22 and TNF-alpha, but not IFN-gamma, IL-4, or IL-17. In analogy to the Th17 subset, cells with this cytokine profile have been named...

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PMID: 19920355
DOI: 10.1172/jci40202

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