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Human Dermal Fibroblast-derived Spheroids Demonstrate Efficacious Immune Modulation in a Psoriasis Mouse Model

2025-08-06

Abstract excerpt

<h4>Background</h4> Psoriasis is a chronic inflammatory disease associated with high morbidity and few cases of sustained remission. Innovative immunomodulatory therapies, including fibroblast-based cell therapies, offer promising alternatives. This study investigates the therapeutic potential of human dermal fibroblasts (HDFs) organized into three-dimensional (3D) spheroids in a mouse model of imiquimod (IMQ)-in...

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Literature Corpus work
19ab64e1-68fc-5484-91c8-0326a75ab2ac
DOI
10.1101/2025.08.04.668478
Open publication

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Human Dermal Fibroblast-derived Spheroids Demonstrate Efficacious Immune Modulation in a Psoriasis Mouse ModelDOI 10.1101/2025.08.04.668478
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