Article
Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians.
Diabetes - 1 Dec 2002
Rasmussen Søren K, Urhammer Søren A, Berglund Lars, Jensen Jan N, Hansen Lars, Echwald Søren M, Borch-Johnsen Knut, Horikawa Yukio, Mashima Hirosato, Lithell Hans, Cox Nancy J, Hansen Torben, Bell Graeme I, Pedersen Oluf
Abstract excerpt
Variations in the calpain-10 gene (CAPN10) have been identified among Mexican-Americans, and an at-risk haplotype combination (112/121) defined by three polymorphisms, UCSNP-43, -19, and -63, confers increased risk of type 2 diabetes. Here we examine the three polymorphisms in 1,594 Scandinavian subjects, including 409 type 2 diabetic patients, 200 glucose-tolerant control subjects, 322 young healthy subjects,...
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