Article
Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb.
Cancer cell - 1 Nov 2002
Bruno Tiziana, De Angelis Roberta, De Nicola Francesca, Barbato Christian, Di Padova Monica, Corbi Nicoletta, Libri Valentina, Benassi Barbara, Mattei Elisabetta, Chersi Alberto, Soddu Silvia, Floridi Aristide, Passananti Claudio, Fanciulli Maurizio
Abstract excerpt
DNA tumor virus oncoproteins bind and inactivate Rb by interfering with the Rb/HDAC1 interaction. Che-1 is a recently identified human Rb binding protein that inhibits the Rb growth suppressing function. Here we show that Che-1 contacts the Rb pocket region and competes with HDAC1 for Rb binding...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.