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Article

Human polyomavirus BKV transcriptionally activates DNA methyltransferase 1 through the pRb/E2F pathway.

Oncogene - 4 May 2006

McCabe M T, Low J A, Imperiale M J, Day M L

Abstract excerpt

Many DNA tumor virus oncogenes are capable of activating and highjacking the host cell's DNA replication machinery for its own reproduction purposes through targeting and inactivation of the retinoblastoma pocket protein family. Pocket proteins function to regulate cell cycle progression and DNA synthesis through inhibitory interactions with the E2F transcription factors. The interaction of viral oncogenes with...

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Share to Adenovirus E1A Proteins
Share to Antigens, Polyomavirus Transforming

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BK Virus

Share to Cell Transformation, Viral

Share to DNA (Cytosine-5-)-Methyltransferase 1

Share to DNA (Cytosine-5-)-Methyltransferases

Share to E2F Transcription Factors

Share to Polyomavirus Infections

Source

Identifiers

PMID: 16547506
DOI: 10.1038/sj.onc.1209266

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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