Article
Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis.
Molecular and cellular neurosciences - 1 Dec 2003
Barbato Christian, Corbi Nicoletta, Canu Nadia, Fanciulli Maurizio, Serafino Annalucia, Ciotti MariaTeresa, Libri Valentina, Bruno Tiziana, Amadoro Giuseppina, De Angelis Roberta, Calissano Pietro, Passananti Claudio
Abstract excerpt
Che-1 is a recently identified human Rb binding protein that inhibits the Rb growth-suppressing function and regulates cell proliferation. Che-1 contacts the Rb and competes with HDAC1 for Rb-binding site, removing HDAC1 from the Rb/E2F cell cycle-regulated promoters. We have investigated the exp...
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