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Article

Che-1 gene silencing induces osteosarcoma cell apoptosis by inhibiting mutant p53 expression.

Biochemical and biophysical research communications - 22 Apr 2016

Liu Ming, Wang Dan, Li Ning

Abstract excerpt

The transcriptional cofactor Che-1 is an RNA polymerase II (Pol II) which is involved in tumorigenesis, such as breast cancer and multiple myeloma. Che-1 can also regulate mutant p53 expression, which plays roles in many types of cancer. In this study, we aimed to investigate the effects and specific mechanism of Che-1 in the regulation of osteosarcoma (OS) cell growth. We found that Che-1 is highly expressed in...

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Identifiers

PMID: 27012205
DOI: 10.1016/j.bbrc.2016.03.073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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