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Article

Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response.

The Journal of cell biology - 31 Mar 2003

Kao Gary D, McKenna W Gillies, Guenther Matthew G, Muschel Ruth J, Lazar Mitchell A, Yen Tim J

Abstract excerpt

Anumber of proteins are recruited to nuclear foci upon exposure to double-strand DNA damage, including 53BP1 and Rad51, but the precise role of these DNA damage-induced foci remain unclear. Here we show in a variety of human cell lines that histone deacetylase (HDAC) 4 is recruited to foci with kinetics similar to, and colocalizes with, 53BP1 after exposure to agents causing double-stranded DNA breaks. HDAC4 foci...

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Source

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Identifiers

PMID: 12668657
DOI: 10.1083/jcb.200209065
PMCID: PMC2172769

Genes

HDAC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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