Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The C-terminus of p63 contains multiple regulatory elements with different functions.

Cell death & disease - 1 Jan 2010

Straub W E, Weber T A, Schäfer B, Candi E, Durst F, Ou H D, Rajalingam K, Melino G, Dötsch V

Abstract excerpt

The transcription factor p63 is expressed as at least six different isoforms, of which two have been assigned critical biological roles within ectodermal development and skin stem cell biology on the one hand and supervision of the genetic stability of oocytes on the other hand. These two isoforms contain a C-terminal inhibitory domain that negatively regulates their transcriptional activity. This inhibitory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Protein Binding
Share to Protein Isoforms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Structure, Tertiary

Share to Sumoylation

Share to Trans-Activators

Share to Transcription, Genetic

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21364624
DOI: 10.1038/cddis.2009.1
PMCID: PMC3032508

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The C-terminus of p63 contains multiple regulatory elements with different functions.PMID 21364624Read ↗

A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism.Semantic proximity Read ↗

Deletion of p63 exon 13 in mice reveals C-terminal isoform–specific functions in epithelial developmentSemantic proximity Read ↗

Distinct interactors define the p63 transcriptional signature in epithelial development or cancerSemantic proximity Read ↗

Allele-specific silencing of EEC p63 mutant R304W restores p63 transcriptional activity.Semantic proximity Read ↗

Differential transcriptional activity of ΔNp63β is encoded by an isoform-specific C-terminusSemantic proximity Read ↗

Identification and functional characterization of two new transcriptional variants of the human p63 geneSemantic proximity Read ↗

Itch/AIP4 associates with and promotes p63 protein degradation.Semantic proximity Read ↗

Role of chromatin and transcriptional co-regulators in mediating p63-genome interactions in keratinocytesSemantic proximity Read ↗

Targeted p63 isoform switch corrects dominant mutations in AEC syndrome without disrupting epidermal homeostasisSemantic proximity Read ↗

An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionarily conserved enhancer.Semantic proximity Read ↗

Transcriptional Network of p63 in Human KeratinocytesSemantic proximity Read ↗

DNA-Binding and Transactivation Activities Are Essential for TAp63 Protein DegradationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.