Article
Parallel genotyping of human SNPs using generic high-density oligonucleotide tag arrays.
Genome research - 1 Jun 2000
Fan J B, Chen X, Halushka M K, Berno A, Huang X, Ryder T, Lipshutz R J, Lockhart D J, Chakravarti A
Abstract excerpt
Large scale human genetic studies require technologies for generating millions of genotypes with relative ease but also at a reasonable cost and with high accuracy. We describe a highly parallel method for genotyping single nucleotide polymorphisms (SNPs), using generic high-density oligonucleotide arrays that contain thousands of preselected 20-mer oligonucleotide tags. First, marker-specific primers are used in...
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