Article
Inhibition of UV-induced p53 mutations and skin cancers by sunscreens: implication for skin cancer prevention.
Experimental dermatology - 1 Jan 2002
Ananthaswamy Honnavara N, Ullrich Stephen E, Kripke Margaret L
Abstract excerpt
The relationship between exposure to UVB radiation and development of skin cancer has been well established. Several studies have shown that UVB induces unique mutations (C to T and CC to TT transitions) in the p53 tumor suppressor gene that are not commonly induced by other carcinogens. Our studies have demonstrated that UV-induced mouse skin cancers contain p53 mutations at a high frequency and that these...
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