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Article

The first inner loop of endothelin receptor type B is necessary for specific coupling to Galpha 13.

The Journal of biological chemistry - 24 Jan 2003

Liu Bo, Wu Dianqing

Abstract excerpt

Endothelin (EDN) receptor type B (EDNRB) activates serum response factor (SRF) via G(q/11) and G(12/13) G proteins. In this study, we investigated the involvement of intracellular loop sequences of EDNRB in coupling to these G proteins. EDNRB mutants were generated and tested for their abilities to activate SRF in NIH3T3 cells and in the mouse embryonic fibroblast cell line (F(q/11)) lacking both Galpha(q) and...

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Source

Identifiers

PMID: 12441350
DOI: 10.1074/jbc.M208683200

Genes

EDNRB
SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The first inner loop of endothelin receptor type B is necessary for specific coupling to Galpha 13.PMID 12441350Read ↗

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