Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of FQQI motif in the internalization, trafficking, and signaling of guanylyl-cyclase/natriuretic peptide receptor-A in cultured murine mesangial cells.

American journal of physiology. Renal physiology - 1 Jan 2016

Mani Indra, Garg Renu, Pandey Kailash N

Abstract excerpt

Binding of the cardiac hormone atrial natriuretic peptide (ANP) to transmembrane guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA), produces the intracellular second messenger cGMP in target cells. To delineate the critical role of an endocytic signal in intracellular sorting of the receptor, we have identified a FQQI (Phe(790), Gln(791), Gln(792), and Ile(793)) motif in the carboxyl-terminal region of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic GMP
Share to Endosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysosomal Membrane Proteins

Share to Lysosomes

Share to rab GTP-Binding Proteins

Share to Receptors, Atrial Natriuretic Factor

Share to Second Messenger Systems

Share to Vesicular Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26377794
DOI: 10.1152/ajprenal.00205.2015
PMCID: PMC4675805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of FQQI motif in the internalization, trafficking, and signaling of guanylyl-cyclase/natriuretic peptide receptor-A in cultured murine mesangial cells.PMID 26377794Read ↗

Internalization and trafficking of guanylyl (guanylate) cyclase/natriuretic peptide receptor A is regulated by an acidic tyrosine-based cytoplasmic motif GDAY.Semantic proximity Read ↗

Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A.Semantic proximity Read ↗

Atypical signaling and functional desensitization response of MAS receptor to peptide ligands.Semantic proximity Read ↗

C-terminal di-leucine motif of dopamine D₁ receptor plays an important role in its plasma membrane trafficking.Semantic proximity Read ↗

The genetic contribution of the natriuretic peptide system to cardiovascular diseases.Semantic proximity Read ↗

Identification of a putative nuclear localization sequence within ANG II AT(1A) receptor associated with nuclear activation.Semantic proximity Read ↗

Interaction of the alpha(1B)-adrenergic receptor with gC1q-R, a multifunctional protein.Semantic proximity Read ↗

Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type MaroteauxSemantic proximity Read ↗

Functions of the cytoplasmic tails of the human receptor activity-modifying protein components of calcitonin gene-related peptide and adrenomedullin receptors.Semantic proximity Read ↗

Cytosolic dynamics of annexin A6 trigger feedback regulation of hypertrophy via atrial natriuretic peptide in cardiomyocytes.Semantic proximity Read ↗

A conserved motif for the transport of G protein-coupled receptors from the endoplasmic reticulum to the cell surface.Semantic proximity Read ↗

N-glycosylation of the human neuropeptide QRFP receptor (QRFPR) is essential for ligand binding and receptor activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.