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Article

Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficient mice models.

Brain research - 27 Oct 2009

Jamal Mostofa, Ameno Kiyoshi, Miki Takanori, Wang Weihuan, Kumihashi Mitsuru, Isse Toyohi, Kawamoto Toshihiro, Kitagawa Kyoko, Nakayama Keiichi, Ijiri Iwao, Kinoshita Hiroshi

Abstract excerpt

We investigated the effects of alcohol (EtOH) and acetaldehyde (ACe) on choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) in the frontal cortex of Aldh2-/- (KO) mice. KO mice were used as models of Aldh2-deficient humans to examine ACe effects. Brain samples were analyzed at 40 and 120 min after 2- and 4-g/kg intraperitoneal EtOH administration by RT-PCR and Western blot. Wild-type (WT) mice...

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Identifiers

PMID: 19664611
DOI: 10.1016/j.brainres.2009.07.099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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