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Article

Molecular characterization of an atl null mutant of Staphylococcus aureus.

Microbiology and immunology - 1 Jan 2002

Takahashi Junko, Komatsuzawa Hitoshi, Yamada Sakuo, Nishida Tetsuya, Labischinski Harald, Fujiwara Tamaki, Ohara Masaru, Yamagishi Jun-ichi, Sugai Motoyuki

Abstract excerpt

atl is a gene encoding a bifunctional peptidoglycan hydrolase of Staphylococcus aureus. The gene product of atl is a 138 kDa protein that has an amidase domain and a glucosaminidase domain, and undergoes processing to generate two major peptidoglycan hydrolases, a 51 kDa glucosaminidase and a 62 kDa amidase in culture supernatant. An atl null mutant was isolated by allelic replacement and characterized. The...

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PMID: 12437027
DOI: 10.1111/j.1348-0421.2002.tb02741.x

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