New insights in the coordinated amidase and glucosaminidase activity of the major autolysin (Atl) in Staphylococcus aureus.

Abstract excerpt

After bacterial cell division, the daughter cells are still covalently interlinked by the peptidoglycan network which is resolved by specific hydrolases (autolysins) to release the daughter cells. In staphylococci, the major autolysin (Atl) with its two domain enzymes, N-acetylmuramyl-L-alanine amidase (AmiA) and β-N-acetylglucosaminidase (GlcA), resolves the peptidoglycan to release the daughter cells. Internal...

Topics

• Amidohydrolases
• Bacterial Proteins
• Gene Expression Regulation, Bacterial
• Gene Expression Regulation, Enzymologic
• Hexosaminidases
• Muramidase
• Mutation
• N-Acetylmuramoyl-L-alanine Amidase
• Staphylococcus aureus