Article
Core binding factor beta (Cbfβ) controls the balance of chondrocyte proliferation and differentiation by upregulating Indian hedgehog (Ihh) expression and inhibiting parathyroid hormone-related protein receptor (PPR) expression in postnatal cartilage and bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2014
Tian Fei, Wu Mengrui, Deng Lianfu, Zhu Guochun, Ma Junqing, Gao Bo, Wang Lin, Li Yi-Ping, Chen Wei
Abstract excerpt
Core binding factor beta (Cbfβ) is essential for embryonic bone morphogenesis. Yet the mechanisms by which Cbfβ regulates chondrocyte proliferation and differentiation as well as postnatal cartilage and bone formation remain unclear. Hence, using paired-related homeobox transcription factor 1-Cre (Prx1-Cre) mice, mesenchymal stem cell-specific Cbfβ-deficient (Cbfβ(f/f) Prx1-Cre) mice were generated to study the...
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