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Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta.

29 Oct 1996

Abstract excerpt

Core binding factor beta (CBF beta) is considered to be a transcriptional coactivator that dimerizes with transcription factors core binding factor alpha 1 (CBFA1), -2, and -3, and enhances DNA binding capacity of these transcription factors. CBF beta and CBFA2, which is also called acute myeloid leukemia 1 gene, are frequently involved in chromosomal translocations in human leukemia. To elucidate the function of...

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PMID: 8901586
DOI: 10.1073/pnas.93.22.12359

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