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Article

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.

Cell - 15 Nov 1996

Wang Q, Stacy T, Miller J D, Lewis A F, Gu T L, Huang X, Bushweller J H, Bories J C, Alt F W, Ryan G, Liu P P, Wynshaw-Boris A, Binder M, Marín-Padilla M, Sharpe A H, Speck N A

Abstract excerpt

The CBFbeta subunit is the non-DNA-binding subunit of the heterodimeric core-binding factor (CBF). CBFbeta associates with DNA-binding CBFalpha subunits and increases their affinity for DNA. Genes encoding the CBFbeta subunit (CBFB) and one of the CBFalpha subunits (CBFA2, otherwise known as AML1...

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Source

Identifiers

PMID: 8929538
DOI: 10.1016/s0092-8674(00)81389-6

Genes

CBFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8929538-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.PMID 8929538Read ↗

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Core-binding factor beta interacts with Runx2 and is required for skeletal development.Semantic proximity Read ↗

Core binding factor at the crossroads: Determining the fate of the HSCSemantic proximity Read ↗

The B subunit of the CCAAT box binding transcription factor complex (CBF/NF-Y) is essential for early mouse development and cell proliferation.Semantic proximity Read ↗

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