Article
The role of the hydrophobic distal heme pocket of CooA in ligand sensing and response.
The Journal of biological chemistry - 24 Jan 2003
Youn Hwan, Kerby Robert L, Roberts Gary P
Abstract excerpt
CooA from Rhodospirillum rubrum is a heme-containing transcriptional activator that becomes activated only upon binding CO. The basis for this specificity has been probed in a CooA variant, termed DeltaP3R4 CooA, lacking two residues adjacent to the Pro(2) heme ligand, which weakens that ligand. DeltaP3R4 CooA can bind imidazole and CN(-), as well as CO, and form a 6-coordinate low spin adduct with each. However,...
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