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Article

The role of the hydrophobic distal heme pocket of CooA in ligand sensing and response.

The Journal of biological chemistry - 24 Jan 2003

Youn Hwan, Kerby Robert L, Roberts Gary P

Abstract excerpt

CooA from Rhodospirillum rubrum is a heme-containing transcriptional activator that becomes activated only upon binding CO. The basis for this specificity has been probed in a CooA variant, termed DeltaP3R4 CooA, lacking two residues adjacent to the Pro(2) heme ligand, which weakens that ligand....

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Identifiers

PMID: 12433917
DOI: 10.1074/jbc.M210825200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12433917-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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