Article
Metal sensing and signal transduction by CnrX from Cupriavidus metallidurans CH34: role of the only methionine assessed by a functional, spectroscopic, and theoretical study.
Metallomics : integrated biometal science - 1 Feb 2014
Trepreau Juliette, Grosse Cornelia, Mouesca Jean-Marie, Sarret Géraldine, Girard Eric, Petit-Haertlein Isabelle, Kuennemann Sandra, Desbourdes Céline, de Rosny Eve, Maillard Antoine P, Nies Dietrich H, Covès Jacques
Abstract excerpt
When CnrX, the periplasmic sensor protein in the CnrYXH transmembrane signal transduction complex of Cupriavidus metallidurans CH34, binds the cognate metal ions Ni(II) or Co(II), the ECF-type sigma factor CnrH is made available in the cytoplasm for the RNA-polymerase to initiate transcription at the cnrYp and cnrCp promoters. Ni(II) or Co(II) are sensed by a metal-binding site with a N3O2S coordination sphere...
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