Redox-controlled ligand exchange of the heme in the CO-sensing transcriptional activator CooA.

doi:10.1074/jbc.273.40.25757

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Article

Redox-controlled ligand exchange of the heme in the CO-sensing transcriptional activator CooA.

The Journal of biological chemistry - 2 Oct 1998

Aono S, Ohkubo K, Matsuo T, Nakajima H

Abstract excerpt

The transcriptional activator CooA from Rhodospirillum rubrum contains a b-type heme that acts as a CO sensor in vivo. CooA is the first example of a transcriptional regulator containing a heme as a prosthetic group and of a hemeprotein in which CO plays a physiological role. In this study, we co...

Topics

Bacterial Proteins
Carbon Monoxide
Electron Spin Resonance Spectroscopy
Genes, Reporter
Heme
Hemeproteins
Lac Operon
Ligands
Mutation
Oxidation-Reduction
Recombinant Proteins
Rhodospirillum rubrum
Spectrophotometry
Trans-Activators
Transcriptional Activation

Source

Open in PubMed

Identifiers

PMID: 9748246
DOI: 10.1074/jbc.273.40.25757

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9748246-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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