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Article

Modulation of NO binding to cytochrome c' by distal and proximal haem pocket residues.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry - 1 May 2008

Barbieri Sonia, Murphy Loretta M, Sawers R Gary, Eady Robert R, Hasnain S Samar

Abstract excerpt

We have cloned and expressed the cycP gene encoding cytochrome c' from Alcaligenes xylosoxidans and generated mutations in Arg-124 and Phe-59, residues close to the haem, to probe their involvement in modulating the unusual spin-state equilibrium of the haem Fe and the unique proximal mode of binding of NO to form a stable five-coordinate adduct. Arg-124 is located in the proximal pocket of the haem and forms a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18259785
DOI: 10.1007/s00775-008-0341-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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