Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel heme ligand displacement by CO in the soluble hemophore HasA and its proximal ligand mutants: implications for heme uptake and release.

Biochemistry - 19 Feb 2008

Lukat-Rodgers Gudrun S, Rodgers Kenton R, Caillet-Saguy Celia, Izadi-Pruneyre Nadia, Lecroisey Anne

Abstract excerpt

HasASM, a hemophore secreted by the Gram-negative bacteria Serratia marcescens, extracts heme from host hemoproteins and shuttles it to HasRSM, a specific hemophore outer membrane receptor. Heme iron in HasASM is in a six-coordinate ferric state. It is linked to the protein by the heretofore uncommon axial ligand set, His32 and Tyr75. A third residue of the heme pocket, His83, plays a crucial role in heme...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbon Monoxide
Share to Heme

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrogen Bonding

Share to Ligands

Share to Models, Molecular

Share to Molecular Probes

Share to Oxidation-Reduction

Share to Spectrum Analysis, Raman

Source

Identifiers

PMID: 18205408
DOI: 10.1021/bi7019518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel heme ligand displacement by CO in the soluble hemophore HasA and its proximal ligand mutants: implications for heme uptake and release.PMID 18205408Read ↗

Haemophore-mediated bacterial haem transport: evidence for a common or overlapping site for haem-free and haem-loaded haemophore on its specific outer membrane receptor.Semantic proximity Read ↗

The heme transfer from the soluble HasA hemophore to its membrane-bound receptor HasR is driven by protein-protein interaction from a high to a lower affinity binding site.Semantic proximity Read ↗

Heme and a five-amino-acid hemophore region form the bipartite stimulus triggering the has signaling cascade.Semantic proximity Read ↗

The C-helix in CooA rolls upon CO binding to ferrous heme.Semantic proximity Read ↗

Critical assessment of the FeC and CO bond strength in carboxymyoglobin: a QM/MM local vibrational mode study.Semantic proximity Read ↗

Redox-controlled ligand exchange of the heme in the CO-sensing transcriptional activator CooA.Semantic proximity Read ↗

A new type of hemophore-dependent heme acquisition system of Serratia marcescens reconstituted in Escherichia coli.Semantic proximity Read ↗

Identification of Cys94 as the distal ligand to the Fe(III) heme in the transcriptional regulator RcoM-2 from Burkholderia xenovorans.Semantic proximity Read ↗

Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation.Semantic proximity Read ↗

CO-dependent activity-controlling mechanism of heme-containing CO-sensor protein, neuronal PAS domain protein 2.Semantic proximity Read ↗

The effect of a C298D mutation in CaHydA [FeFe]-hydrogenase: Insights into the protein-metal cluster interaction by EPR and FTIR spectroscopic investigation.Semantic proximity Read ↗

Staphylococcus aureus Uses a Novel Multidomain Receptor to Break Apart Human Hemoglobin and Steal Its HemeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.