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Article

Generating a Metal-responsive Transcriptional Regulator to Test What Confers Metal Sensing in Cells.

The Journal of biological chemistry - 7 Aug 2015

Osman Deenah, Piergentili Cecilia, Chen Junjun, Chakrabarti Buddhapriya, Foster Andrew W, Lurie-Luke Elena, Huggins Thomas G, Robinson Nigel J

Abstract excerpt

FrmR from Salmonella enterica serovar typhimurium (a CsoR/RcnR-like transcriptional de-repressor) is shown to repress the frmRA operator-promoter, and repression is alleviated by formaldehyde but not manganese, iron, cobalt, nickel, copper, or Zn(II) within cells. In contrast, repression by a mutant FrmRE64H (which gains an RcnR metal ligand) is alleviated by cobalt and Zn(II). Unexpectedly, FrmR was found to...

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Identifiers

PMID: 26109070
DOI: 10.1074/jbc.M115.663427
PMCID: PMC4528141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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