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Genomic profile of chronic myelogenous leukemia: Imbalances associated with disease progression

15 Aug 2007

Abstract excerpt

The expression of the chimeric BCR/ABL1 fusion gene resulting from t(9;22)(q34;q11) in chronic myelogenous leukemia (CML) is necessary for malignant transformation, but not sufficient to maintain disease progression. The appearance of various chromosomal and molecular alterations in the accelerated and terminal phase of CML is well documented, but evidence for causal relationship is largely lacking. We carried...

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PMID: 17696194
DOI: 10.1002/gcc.20487

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