Article
BCR/ABL genes and leukemic phenotype: from molecular mechanisms to clinical correlations.
Oncogene - 9 Dec 2002
Pane Fabrizio, Intrieri Mariano, Quintarelli Concetta, Izzo Barbara, Muccioli Giada Casadei, Salvatore Francesco
Abstract excerpt
The Philadelphia chromosome (Ph), a minute chromosome that derives from the balanced translocation between chromosomes 9 and 22, was first described in 1960 and was for a long time the only genetic lesion consistently associated with human cancer. This chromosomal translocation results in the fusion between the 5' part of BCR gene, normally located on chromosome 22, and the 3' part of the ABL gene on chromosome 9...
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