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Genomic Mechanisms Influencing Outcome in Chronic Myeloid Leukemia

26 Jan 2022

Abstract excerpt

Chronic myeloid leukemia (CML) represents the disease prototype of genetically based diagnosis and management. Tyrosine kinase inhibitors (TKIs), that target the causal BCR::ABL1 fusion protein, exemplify the success of molecularly based therapy. Most patients now have long-term survival; however, TKI resistance is a persistent clinical problem. TKIs are effective in the BCR::ABL1-driven chronic phase of CML but...

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PMID: 35158889
DOI: 10.3390/cancers14030620

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