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BCR-ABL: The molecular mastermind behind chronic myeloid leukemia

10 May 2025

Abstract excerpt

The chromosomal translocation t(9;22)(q34;q11), known as the Philadelphia (Ph) chromosome, results in the BCR-ABL gene fusion which gives rise to Chronic Myeloid Leukemia (CML), a slowly progressing hematopoietic cancer that begins in the bone marrow of the patient. Making up about 15 % of all new leukemia cases, CML remains a critical focus of cancer research and treatment due to its distinctive genetic...

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PMID: 40360311
DOI: 10.1016/j.cytogfr.2025.05.001

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