Article
Hepatocytes buried in the cirrhotic livers of patients with biliary atresia proliferate and function in the livers of urokinase-type plasminogen activator-NOG mice.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society - 1 Sept 2014
Suemizu Hiroshi, Nakamura Kazuaki, Kawai Kenji, Higuchi Yuichiro, Kasahara Mureo, Fujimoto Junichiro, Tanoue Akito, Nakamura Masato
Abstract excerpt
The pathogenesis of biliary atresia (BA), which leads to end-stage cirrhosis in most patients, has been thought to inflame and obstruct the intrahepatic and extrahepatic bile ducts. BA is not believed to be caused by abnormalities in parenchymal hepatocytes. However, there has been no report of a detailed analysis of hepatocytes buried in the cirrhotic livers of patients with BA. Therefore, we evaluated the...
Topics
- ATP-Binding Cassette Transporters
- Adult
- Animals
- Bile
- Biliary Atresia
- Biomarkers
- Cell Proliferation
- Child
- Child, Preschool