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Article

Predictability of mutant sequences. Relationships between mutational mechanisms and mutant specificity.

Annals of the New York Academy of Sciences - 18 May 1999

Ripley L S

Abstract excerpt

Spontaneous mutations are rare and are produced by multiple biochemical mechanisms. Nonetheless, studies of these mechanisms have revealed striking examples in which mutational specificity can be regularly related to a characteristic of the surrounding DNA sequence and/or the enzymes participating in mutagenesis. Thus, to an increasing degree the DNA sequences of mutants are "predictable." This report considers...

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PMID: 10415481
DOI: 10.1111/j.1749-6632.1999.tb08877.x

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