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Article

Hsc70 is required for endocytosis and clathrin function in Drosophila.

The Journal of cell biology - 11 Nov 2002

Chang Henry C, Newmyer Sherri L, Hull Michael J, Ebersold Melanie, Schmid Sandra L, Mellman Ira

Abstract excerpt

By screening for Drosophila mutants exhibiting aberrant bride of sevenless (Boss) staining patterns on eye imaginal disc epithelia, we have recovered a point mutation in Hsc70-4, the closest homologue to bovine clathrin uncoating ATPase. Although the mutant allele was lethal, analysis of mutant clones generated by FLP/FRT recombination demonstrated that the Sevenless-mediated internalization of Boss was blocked...

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Identifiers

PMID: 12427870
DOI: 10.1083/jcb.200205086
PMCID: PMC2173062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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