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Article

Tissue-specific expression of dominant negative mutant Drosophila HSC70 causes developmental defects and lethality.

Molecular biology of the cell - 1 Jul 1999

Elefant F, Palter K B

Abstract excerpt

The Drosophila melanogaster HSC3 and HSC4 genes encode Hsc70 proteins homologous to the mammalian endoplasmic reticulum (ER) protein BiP and the cytoplasmic clathrin uncoating ATPase, respectively. These proteins possess ATP binding/hydrolysis activities that mediate their ability to aid in protein folding by coordinating the sequential binding and release of misfolded proteins. To investigate the roles of HSC3...

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Identifiers

PMID: 10397752
DOI: 10.1091/mbc.10.7.2101
PMCID: PMC25422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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